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Comparison of High flow nasal oxygen and Bilevel Positive Airway pressure for prevention of extubation failure in ICU patients

Study to compare the effectiveness of High Flow Nasal Cannula (HFNC) vs BiPAP to prevent reintubation in patients of high risk of extubation failure in ICU Setup.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/035131
Enrollment
60
Registered
2021-07-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: High Flow Nasal Cannula: High Flow Nasal Cannula to deliver heated & humidified oxygen flow 30L/min. Control Intervention1: Bilevel Positive Pressure (BiPAP): A non invasive ventilation

Sponsors

Nisha Kumari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients intubated for more than 24hrs Underlying Cardiac and Pulmonary Disease Conscious and Cooperative Patients

Exclusion criteria

Exclusion criteria: Contradictions to HFNC and BiPAP Unconscious and Non cooperative patients GCS Patient Refusal Muscle Paralysis Traumatic Brain Injury Self Extubation

Design outcomes

Primary

MeasureTime frame
To compare the incidence of reintubation within 5 days of extubationTimepoint: If patients need reintubation within 5 days of extubation then it would be considered as failure of HFNC and BiPAP—

Secondary

MeasureTime frame
To assess the comfort and acceptability of therapy by patients using questionnaireTimepoint: 18 months;To monitor hemodynamic and respiratory parameter till Day 5 post extubationTimepoint: 18 months;To see incidence of reintubation within 48hrs and 72hrs of extubationTimepoint: 18 months—

Countries

India

Contacts

Public ContactDr Sanjeev Kumar

Indira Gandhi Institute Of Medical Sciences

nisharajak4u@gmail.com9006192623

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026