Clinical trial to compare the effects of norepinephrine and phenylephrine infusion in prevention of hypotension after spinal anaesthesia in elective cesarean section

Comparison of Norepinephrine and Phenylephrine infusion for prevention of hypotension after spinal anaesthesia in patients undergoing elective cesarean section

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/035125

Enrollment

Registered

2021-07-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Iv infusion of norepinephrine: Iv infusion of the norepiinephrine will be started after the csf tap and stopped at clamping of umbelical cord and delivery of the baby. Control Intervent

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women with singleton pregnancy with age between 18years and 40years and gestation period between 36weeks to 40 weeks who comes under The American Society of Anaesthesiologists physical status â?¡ who are undergoing cesarean section under spinal anaesthesia

Exclusion criteria

Exclusion criteria: 1.Refusal for study 2.allergic to local anaesthetics or study drug 3.infection at insertion site 4.use of cardiac medication or medication for blood pressure control ,cardiovascular disease,hypertensive disorders of pregnancy ,eclamsia 5.Gestation diabetes requiring insulin 6.History of post operative nausea and vomiting 7.History of chronic opioid use(chronic pain syndrome) 8.cesarean delivery for maternal and/or fetal distress

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of infusion of norepinephrine and infusion of phenylephrine for prevention of hypotension after spinal anaesthesia in elective cesarean sectionTimepoint: To comapare number of rescue boluses of ephedrine 0.6 mg to treat hypotension in both the groups from the time of sub arachnoid block till completion of surgery	—

Secondary

Measure	Time frame
Two compare the following between two groups Hemodynamic parameters like heart rate,respiratory rate,spo2 incidence of adverse effects neonatal apgar score at 1min and 5 min neonatal umbelical vein sample for ph,po2,hco3Timepoint: heart rate less than 60,nausea and vomiting,apgar score intraoperatively till the end of surgery	—

Countries

India

Contacts

Public ContactShridevi P Edigar

Dr S N Medical college Jodhpur

Sarita.janweja@gmail.com9829116420

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026