The Effect of Vitamin C and Thiamine in Sepsis

The Effect of Vitamin C and Thiamine in Sepsis: An Open Label Randomised Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/035107

Enrollment

Registered

2021-07-26

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

Intervention1: Vitamin C and Thiamine: 1) Inj Vitamin C 1.5 grams IV every 6th hourly for four days 2) Inj Thiamine 200 mg IV every 12th hourly for four days Control Intervention1: No placebo is used.

Eligibility

Inclusion criteria

Inclusion criteria: Critically ill patients aged 18 to 65 years, clinically suspected to have infection are included

Exclusion criteria

Exclusion criteria: Septic shock (SBP End Stage Renal Disease Hemochromatosis Known allergy to Vitamin C Pregnancy and lactation Clinically indications requiring thiamine therapy

Design outcomes

Primary

Measure	Time frame
28 day survival after starting interventionTimepoint: 28 days	—

Secondary

Measure	Time frame
90 day survival after starting intervention Duration of ICU Stay Requirement of inotrope support Requirement of ventilator supportTimepoint: 90 days	—

Countries

India

Contacts

Public ContactDr T N C Pranav

JIPMER

drvenks@gmail.com09488505555

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026