Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Epidural Morphine: Patients with High Respiratory Drive ( TFDi 30%) will be administered Epidural morphine 5 mg -10 mg in escalating doses once every 18-24 hours
Control Intervention1:
Sponsors
Swagata Tripathy
Eligibility
Inclusion criteria
Inclusion criteria: COVID 19 ARDS patients on NIV, P/F Ration 30% ( secondary - Vt > 10 ml/ kg. RR > 25 /min )
Exclusion criteria
Exclusion criteria: Metabolic acidosis HCO3- < 16 or pH < 7.2. Severe hypoxemia warranting cessation of NIV and intubation, non-acceptance of NIV. Technical difficulty for epidural catheterization, coagulation abnormalities, low respiratory drive, EOL orders, chronic opioid use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragm thickening index fractionTimepoint: Average of 3 readings at 3 time points each 24 hours, for the duration of minimum 48 hours and a maximum of 100 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilatory parameters, sedation and pain scores, subjective comfort and dyspnoea scores, time to intubation, length of stay on NIV, 28 day mortality.Timepoint: Average of 3 readings at 3 time points each 24 hours, for the duration of minimum 48 hours and a maximum of 100 hours | — |
Countries
India
Contacts
Public Contactswagata Tripathy
AII India Institute of Medical Sciences
Outcome results
None listed