Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
Conditions
Interventions
Intervention1: Isotonic bicarbonate 1.3% fluid: 10 ml/kg bolus as resuscitation maximum 2 times, f/b 5 ml/kg aliquots if hypovolemic over initial 24 hours of emergency admission
Control Intervention1:
Sponsors
AIIMS new delhi
Eligibility
Inclusion criteria
Inclusion criteria: i) 18 years of age or above, ii) pH =2, v) lactate >= 2 mmol/litre requiring fluid resuscitation
Exclusion criteria
Exclusion criteria: PaCO2 >=45 mm Hg, known chronic kidney disease (CKD) stage >=IV or congestive cardiac failure (CHF) with hypervolemia (as seen on ultrasound and echocardiography), pregnant, already on some form of bicarbonate therapy, unknown poisoning with suspected external acid ingestion. Study design : Prospective randomized control trail (RCT)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference of lactate clearance (LC) at 6 hours, between isotonic bicarbonate and plasmalyte-A group, considering all patients. Timepoint: measuring lactate clearance in two groups at specified time points i.e. 2 hours, 6 hours, 12 hours and at 24 hours after admission | — |
Secondary
| Measure | Time frame |
|---|---|
| change of base excessTimepoint: 2,6,12,24 hours;LCTimepoint: 2,12,24 hours;mortalityTimepoint: 24 hours;pH, osmolarity changesTimepoint: 2,6,12,24 hours;renal replacement therapyTimepoint: within 24 hours;serum electrolytes comparisonTimepoint: 2,6,12,24 hours;vasoactive-inotropic scoreTimepoint: 2,6,12,24 hours | — |
Countries
India
Contacts
Public ContactAvishek Roy
Anesthesia, AIIMS, New Delhi
Outcome results
None listed