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A clinical trial to study the effects of two drugs,Phenylephrine and Norepinephrine in patients undergoing elective cesarean section to prevent and treat fall in blood pressure.

Comparison of Phenylephrine versus Norepinephrine infusion for prevention and treatment of maternal hypotension during spinal anaesthesia for elective cesarean section:A Randomized, double blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/035063
Enrollment
90
Registered
2021-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Probably infusion of norepinephrine in Patients undergoing cesarean section: NE- 1 ampoule of 2ml contain 4mg Noradrenaline base,we take 0.6mg(0.6ml) of this drug and dilute it with 99.

Sponsors

Dr Megha Maheshwari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Women posted for elective cesarean section under spinal anaesthesia with singleton, term, uncomplicated pregnancy 2)Weight between 50 to 100kg 3)Height between 150 to 170cm 4)Women belonging to ASA physical status 2

Exclusion criteria

Exclusion criteria: 1)Patient refusal 2)Patient who are contraindicated for spinal anaesthesia 3)Patient with obstetric complication like preexisting or pregnancy induced hypertension, cardiovascular disease, cerebrovascular disease and preexisting diabetes, gestational diabetes

Design outcomes

Primary

MeasureTime frame
To compare the incidence of maternal bradycardia (less than 55 bpm) between two vasopressors infusionTimepoint: Every 2 minutes after giving spinal anaesthesia till delivery of fetus (cord clamping)

Secondary

MeasureTime frame
1)To compare systolic arterial pressure between two groups 2)To compare frequency of post spinal hypotension and reactive hypertension 3)To compare umbilical artery and vein blood gases between two groups 4)To compare incidence of fetal acidosis(umbilical artery blood pH less than 7.2) 5)To compare Apgar score at 1 and 5 minutes 6)To compare umbilical vein blood glucose level 7)To compare maternal side effects like nausea,vomiting, dizziness,change in skin colorTimepoint: ..;To compare Apgar score at 1 and 5 minutes after delivery of babyTimepoint: 1 and 5 minutes after delivery

Countries

India

Contacts

Public ContactMegha Maheshwari

Hamdard Institute of Medical sciences & New Delhi

drpratibhapanjiar@jamiahamdard.ac.in9311657822

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026