Study of the association between abnormalities in mitochondrial function and Autism Spectrum Disorder (ASD): Can Ayurvedic herbs, that are used to improve intellect, reverse this?

Investigation of mitochondrial dysfunction in Autism Spectrum Disorder (ASD): Evaluation of neuroprotection and reversal of mitochondrial deficits using Ayurvedic Medhya Rasayana therapy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/035048

Enrollment

Registered

2021-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F840- Autistic disorder

Interventions

Intervention1: Ayurvedic Medhya Rasayana Therapy: Medhya Rasayana (herbal medicines beneficial for increasing intellect) mentioned in Ayurveda namely Guduchi (Tinospora cordifolia), Mandukaparni (Cent

Eligibility

Inclusion criteria

Inclusion criteria: Idiopathic cases of autism without any other developmental and neurological diseases Age-matched controls without ASD or any other developmental disorders

Exclusion criteria

Exclusion criteria: Subjects with Fragile-X syndrome and gross chromosomal aberrations and other neurodevelopmental and neurological diseases

Design outcomes

Primary

Measure	Time frame
Reversal of mitochondrial dysfunction and associated symptoms found in autistic children Reversal of behavioral phenotype in autistic childrenTimepoint: At baseline, after 2 months and 3 months	—

Secondary

Measure	Time frame
Assessing severity of autism symptoms using Childhood Autism Rating Scale, Autism Treatment Evaluation Checklist Mitochondrial functional analysis Platelet neurotransmitter analysisTimepoint: Baseline, after 2 and 3 months	—

Countries

India

Contacts

Public ContactJisha P Janardhanan

IUCBR and SSH under Mahatma Gandhi University

usharajamma1962@gmail.com8921408590

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026