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A study to compare the effect of Dexmedetomidine, Midazolam and Saline in the prevention of Etomidate-induced Myoclonus

Attenuation of Etomidate-induced Myoclonus with Dexmedetomidine, Midazolam or Saline - A Randomized Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/035043
Enrollment
90
Registered
2021-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Intravenous Dexmedetomidine: 0.5mcg/kg of Dexmedetomidine IV over 60 seconds, given 2 minutes before induction with 0.3mg/kg of Etomidate Control Intervention1: Intravenous Midazolam: 0

Sponsors

Raghupathi R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I and II 2.Has signed a written informed consent form

Exclusion criteria

Exclusion criteria: 1.Patients with ASA grade III and IV 2.Patients with hepatic,renal,neurological,cardiovascular and respiratory problems 3.History of allergy to study drugs 4.Anticipated diffcult airways 5.Patient who took analgesics drugs preoperatively 6.Patient with morbid obesity and emergency surgery

Design outcomes

Primary

MeasureTime frame
Incidence and severity of MyoclonusTimepoint: 2 minutes—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr N Anita Devi

Regional Institute of Medical Sciences, Imphal, Manipur

dranitadevin@gmail.com9862565742

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026