Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Normal saline: 2 drops of Normal saline in 5 ml distilled water by nebulisation (inhalation), 4 times a day for 3 days followed by 3 times a day for next 4 days, followed by 2 times day
Sponsors
Amol N Patil
Eligibility
Inclusion criteria
Inclusion criteria: 1] Healthy volunteers with normal liver and kidney function, normal hemogram and ECG, urine routine, chest X-ray examination, negative urine drug screen, negative HIV, HCV, HbsAg as assessed by baseline investigations 2] Age between 18 to 55 years 3] Either gender 4] Ready to give consent and willing to undergo experiment and comply with protocol
Exclusion criteria
Exclusion criteria: 1. Age 55 years. 2. Patients with moderate or severe disease. 3. Pregnant and lactating population. 4. Patients not giving consent for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To assess the safety and determine maximum tolerated dose of Essential oil blend nebulization by evaluating the toxicities including: type, frequency, severity, attribution and duration. 2. To assess the efficacy of EOs nebulisation in preventing respiratory symptoms development in asymptomatic and mild disease COVID-19 positive patients 3. To assess the efficacy of EOs nebulisation in respiratory symptom relief in mild disease COVID-19 positive patients. Timepoint: Baseline, Day 3, 5, 7, 10 and !4 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To analyse its role in days to clinical recovery and need of hospitalisation. 2. To analyse time to viral RNA negativity. 3. To assess its effectiveness in relief of symptoms like anosmia, dysgeusia, pharyngitis in mild disease COVID-19 positive patients. Timepoint: Baseline, Day 3, 5, 7, 10 and !4 | — |
Countries
India
Contacts
Public ContactAnkit Kumar
PGIMER Chandigarh
Outcome results
None listed