Health Condition 1: - Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Probiotics VSL#3: Probiotics VSL#3 is
equivalent to more than 112.5 billion colony-forming units (cfu)
contains 8 strains of bacteria
which includes 4 Lactobacillus species (L paracasei DSM 24733, L plantarum DSM 24730, L
acidophilus DSM 24735, and L delbrueckii subspecies bulgaricus DSM 24734), 3
Bifi
Sponsors
Jawarhalal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: a) Males and females aged >18 yrs with Liver cirrhosis of known etiology. b)Active status on the waiting list c) Provide informed consent
Exclusion criteria
Exclusion criteria: a) Pregnancy / under Fertility treatments b)Malignancy except HCC c)Human immunodeficiency virus infection d)Creatinine clearance e)Cystic fibrosis f)Consumption of probiotics in any form within one month prior to participation â??g)Chronic gastrointestinal disorder including inflammatory bowel disease and celiac disease â??h)Chronic immunosuppressive medication usage. i)â??Liver transplantation schedule within six weeks from the day of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of probiotics on nutritional status,intestinal permeability and inflammatory markers in cirrhotic patients waiting for liver transplantation compared to placeboTimepoint: At baseline and after 6 weeks of probiotic supplementation | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the effect of probiotics on liver disease severity in cirrhotic patients waiting for liver transplantation compared to placeboTimepoint: At baseline and after 6 weeks of probiotic supplementation | — |
Countries
India
Contacts
Public ContactR Gokulapriya
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed