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Comparing Midazolam and Dexmedetomidine as sedative and for decreasing anxiety in general anaesthesia in controlled hypertensive patients undergoing elective surgery

COMPARISON OF PREMEDICATION WITH MIDAZOLAM AND DEXMEDETOMIDINE ON SEDATION AND ANXIETY IN CONTROLLED HYPERTENSIVE PATIENTS UNDERGOING ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/034904
Enrollment
100
Registered
2021-07-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: Midazolam: 0.02mg/kg I.v in 100 ml Normal saline over 10 minutes Intervention2: Dexmedetomidine: 1mcg/kg in 100ml normal saline over 10 minutes. Control Intervention1: Drugs: Comparison

Sponsors

ABVIMS DR RML HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age between 20 to 75 years 2.ASA 2

Exclusion criteria

Exclusion criteria: 1.Renal and hepatic dysfunction 2.cardiovascular diseases 3.uncontrolled hypertensive patients 4.Pregnant or lactating 5.opiod use 6.history of drug sensitivity,seizures,psychiatric disorders 7.patient on beta-blockers

Design outcomes

Primary

MeasureTime frame
1.sedation scoring by RSS at 5 minutes interval 2.Anxiety level using VAS-A at 5 minutes intervalTimepoint: 1.sedation scoring by RSS at 5 minutes interval 2.Anxiety level using VAS-A at 5 minutes interval—

Secondary

MeasureTime frame
1.Hemodynamic measurements at 5 minutes interval Mean arterial pressure ,systolic blood pressure,diastolic blood pressure Heart rate Peripheral oxygen saturation Respiratory rateTimepoint: At Baseline—

Countries

India

Contacts

Public ContactNITHISHA ROY

ABVIMS and Dr.RML Hospital

Alkagupta_rml@yahoo.co.in9871653335

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026