Health Condition 1: J09- Influenza due to certain identified influenza viruses
Conditions
Interventions
None listed
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.All patients with age 18 years to 65 years. 2.Confirmed COVID 19 from nasopharyngeal swap by Real time Polymerase chain reaction (RT PCR) 3.Patients admitted to ICU and treated with therapeutic dosage of anti-coagulants. Therapeutic anticoagulation includes patients who receive LMWH at curative dose (100 IU/kg/12 h SC based on actual weight, without exceeding 10,000 IU/12 h or UFH 500 IU/kg/24 h if creatinine clearance
Exclusion criteria
Exclusion criteria: a)Patients who received prophylactic dose anticoagulants. This includes patients treated with standard or reinforced prophylactic dosage of heparin (low molecular weight heparin LMWH-enoxaparinâ??up to 6000 IU/12 h SC in obese patients or unfractionated heparin UFH 200 IU/kg/24 h if creatinine clearance b)Patients with a known bleeding disorder or evidence of active bleeding at the time of admission. c)Any contraindication to the use of Heparin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study will be to assess the incidence of major and clinically relevant nonmajor bleeding among Covid 19 pneumonia patients receiving therapeutic heparin.Timepoint: Day of Icu admission to discharge/death from ICU, could be 2-4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| a)Incidence of each type of thrombotic/ischemic events occurring during ICU stay b)Platelet count and coagulation tests including prothrombin time (PT), antithrombin activity (AT), fibrinogen, D-dimers and activated partial thromboplastin time (aPTT). c)Elevated liver enzymes (AST, ALT more than 3times the normal value) d)Need for mechanical ventilation, e)Duration of ICU stay f)Duration of hospital stay Timepoint: Day of Icu admission to discharge/death from ICU,could be 2-4 weeks. | — |
Countries
India
Contacts
Public ContactAjay Singh
Post Graduate Institute of Medical Education & Research Chandigarh India
Outcome results
None listed