Health Condition 1: J159- Unspecified bacterial pneumonia
Conditions
Interventions
Intervention1: Intravenous Polymyxin B PLUS Aerosolised Colistin: Colistimethate Sodium (Colistin) 5 MIU every 8 hours byvibrating plate nebulizer.
Intravenous Polymyxin B will be administered at 3000
Sponsors
Dr Supradip Ghosh
Eligibility
Inclusion criteria
Inclusion criteria: 1. New onset of fever ( >100.4°F) with or without leukopenia (=12,000 WBC/mm3) 2. New onset of purulent sputum/change in character of sputum/increased respiratory secretions and/or worsening gas exchange 3. Radiological (Chest X-ray or CT Chest) evidence of consolidation. 4. Being on invasive mechanical ventilation anytime within past 48-hours.
Exclusion criteria
Exclusion criteria: 1. Patients 2. Pregnant ladies 3. Refusal of consent 4. Patient already on intravenous polypeptide antibiotics for some other indication or requiring intravenous polypeptide administration for suspicion of other nosocomial infections 5. Known hypersensitivity to Colistin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢ Clinical response rate of intravenous polymyxin B plus aerosolized colistin compared to intravenous polymyxin B alone amongst study subject.Timepoint: At the end of treatment period | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Not Applicable | — |
Countries
India
Contacts
Public ContactDr Supradip Ghosh
Fortis-Escorts Hospital, Faridabad
Outcome results
None listed