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Comparing which amongst the 2 drugs Dexmedetomidine and Clonidine (alpha agonist) when added with ropivacaine (local anaesthetic) drug for epidural anaesthesia in people undergoing lower limb surgeries provides better anaesthesia and pain relief

Comparison Of Dexmedetomidine And Clonidine as an Adjuvant to Ropivacaine for Epidural Anaesthesia in Lower Limb Surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/034853
Enrollment
60
Registered
2021-07-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention1: clonidine plus ropivacaine: patients undergoing lower limb surgery will receive the drugs via epidural at a dose of 0.75% ropivacaine 19 ml and clonidine 1mics/kg Control Intervention1:

Sponsors

Dept of Anaesthesia DR S N MEDICAL COLLEGE
Lead Sponsor
Dept of anaesthesia
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patient belonging to ASA Grade 1 and 2, scheduled for Lower Limb Surgery

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating women. 2. Any contraindications to epidural anaesthesia: patient refusal, uncooperative patients, hypotension, previous spinal surgeries, infection at local site, coagulation abnormalities and patients allergic to amide group of local anaesthetics. 3. Patients with uncontrolled hypertension, and cardiac diseases. 4. Patients with haematological diseases, neuromuscular diseases, severe renal or hepatic derangements. 5. Patients taking tricyclic antidepressants, alpha 2 adrenergic agonists, opioids, anti-arrythmics, beta blockers and anticoagulants.

Design outcomes

Primary

MeasureTime frame
to compare total duration of analgesia obtained on adding dexmedetomidine and clonidine as an adjuvant to epidural anaesthesia in lower limb surgeriesTimepoint: 24 hrs—

Secondary

MeasureTime frame
To compare the Sensory blockade (onset, duration and maximum level of sensory block achieved), motor blockade ( duration and intensity), ability to provide sedation, haemodynamic parameter, intra and post operative complications if any on giving dexmedetomidine plus ropivacaine and clonidine plus ropivacaine in patients undergoing lower limb surgery under epidural anaesthesia.Timepoint: 24 hrs—

Countries

India

Contacts

Public ContactDRFSBHATI

DR. S N MEDICAL COLLEGE

fatehbhati68@gmail.com9414127176

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026