Comparision of different scaffolds for success of regeneration in immature apex

A comparative evaluation of Dexamethasone coated bioglassnanofibre, bioglassnanofibre and PRF scaffold in endodontic regeneration therapy - RCT

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/034841

Enrollment

Registered

2021-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp Health Condition 2: K042- Pulp degeneration

Interventions

Intervention1: Nanobioglass fibre,: Bioglassnanofibres exerts excellent bioactivity2) due to increased surface area Procedure- Initially access cavity will be made under rubber dam isolation.Negoti

Eligibility

Inclusion criteria

Inclusion criteria: 1. Necrotic immature, asymptomatic permanent anterior teeth. 2. Open apex with open apex associated with or without periapical radiolucency 3. Negative response to hot and cold pulp sensitivity tests 4. No tooth mobility and 5. No prior endodontic treatment of involved tooth

Exclusion criteria

Exclusion criteria: Patients with medical conditions like cardiac problems, pregnant patients, diabetic patients, bleeding tendencies, HIV+ patients, hepatitis-B.

Design outcomes

Primary

Measure	Time frame
To analyse post intervention, radiographic dentin thickeness and periapical bone healingTimepoint: 3 months, 6 months, 9 months, 12 months	—

Secondary

Measure	Time frame
apical Closure, Post operative pulp sensiblityTimepoint: 3 months, 6 monthds, 9 months, 12 months	—

Countries

India

Contacts

Public ContactSakshi Gupta

Head of Department Conservative Dentistry and Endodontics

dr.neelammittal@gmail.com9415203360

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026