To assess a method of lung ventilation in manner to protect them functionally during routine operation under general anesthesia about its short term and long term ill effect in patient who have recovered from covid

Comparative evaluation of intraoperative lung protective strategy in the COVID 19 recovered patients undergoing surgery under GA to reduce short term and long term pulmonary complications Pilot study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/034821

Enrollment

Registered

2021-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J984- Other disorders of lung

Interventions

Intervention1: Group 1: Protective Lung Ventilation: Lung-protective ventilation with volume controlled mode by tidal volume of 6–8 ml/kg/predicted body weight, PEEP of 6–8 cmH2O, a plateau pressure (

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex with American Society Anaesthesiologists’ physical status I-II, age between 18 and 70 years, with history of COVID 19 positive more than 3 months duration needed hospitalization and oxygen therapy during active phase) scheduled for surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: The patient with presence of active respiratory tract infection, chronic obstructive lung disease, bronchial asthma and sleep apnoea syndrome, severe cardiovascular diseases, liver or kidney dysfunction, history of second- or third-degree heart block and ischemic heart diseases, body mass index >35 kg/m2 and surgery more than 3 lumbar segments will be excluded.

Design outcomes

Primary

Measure	Time frame
The primary outcome will be a composite of major pulmonary and extra pulmonary complications occurring by day 7 after surgery. Major pulmonary complications will be defined as pneumonia or the need for invasive or non invasive ventilation for acute respiratory failure. Major extra pulmonary complications will be defined as sepsis, severe sepsis and septic shock (defined according to consensus criteria) or death.Timepoint: Preoperative (baseline), Day 1, Day 7 and Day 30	—

Measure

Time frame

The primary outcome will be a composite of major pulmonary and extra pulmonary complications occurring by day 7 after surgery. Major pulmonary complications will be defined as pneumonia or the need for invasive or non invasive ventilation for acute respiratory failure. Major extra pulmonary complications will be defined as sepsis, severe sepsis and septic shock (defined according to consensus criteria) or death.Timepoint: Preoperative (baseline), Day 1, Day 7 and Day 30

—

Secondary

Measure	Time frame
Respiratory dynamics, correlation with PFT and HRCT score with outcome Incidence of pulmonary complicationsTimepoint: 30 days	—

Countries

India

Contacts

Public ContactDr Devendra Gupta

SGPGIMS

drdevendragpt@yahoo.com9919754895

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026