calculation of the effective dose of Levo-bupivacaine(0.5%)and Ropivacaine(0.5%) in unilateral spinal anaesthesia

Determination of the median effective dose(ED50) of Levo-bupivacaine(0.5%)and Ropivacaine(0.5%)in unilateral spinal anaesthesia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/034793

Enrollment

Registered

2021-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj Levo-Bupivacaine 0.5% given intrathecally: The first patient in group L will be received 0.5% Levo-bupivacaine 1ml (5.0â??mg) The testing interval will be 0.5â??mg. If the respons

Eligibility

Inclusion criteria

Inclusion criteria: ASA-I/II Elective unilateral limb(below knee) surgeries like amputation,debridement. Height-between 5feet and 6feet

Exclusion criteria

Exclusion criteria: Patients with absolute and relative contraindications to spinal anaesthesia (Patient refusal, Local skin infection, Vertebral column abnormalities, bleeding disorders, sever hypovolemia, thyroid disorders, cardiopulmonary disease, neuropathies ,severely altered mental status) Patients with history of diabetes, renal or hepatic disease Patients with allergy to local anaesthetics Pregnant and lactating females Morbid obesity(BMI >29 kg/square metre)

Design outcomes

Primary

Measure	Time frame
-sensory and motor characteristics -to observe any changes in hemodynamic parameters like pulse rate,blood pressure,respiratory rate,ECG,SpO2 perioperativelyTimepoint: Time from administration of drug intrathecally till 24 hours	—

Secondary

Measure	Time frame
to observe any complications like bradycardia,hypotention,nausea/vomiting,pruritus,shivering, urinary retention.Timepoint: Time from administration of drug intrathecally till 24 hours	—

Countries

India

Contacts

Public ContactDr Mamta Patel

Goverment Medical College,baroda.

mgpatel111@yahoo.com9825453024

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026