Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Ultra brief pulse ECT (0.25ms): ECT will be given thrice a week for upto 8 sessions in total of 0.25ms pulse width with bitemporal electrode placement, under anesthetic modification at
Sponsors
Central Institute Of Psychiatry Kanke Ranchi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization,1992) 2. Age between 18- 60 years of either sex 3. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7 4. Patients meeting any of the indications of ECT in Schizophrenia (Treatment Guidelines of Indian Psychiatry Society-2017): • Affective Symptoms • Need for rapid control of symptoms • Presence of suicidal behaviour putting patientâ??s life at risk • Presence of severe agitation or violence putting otherâ??s life at risk • Refusal to eat, putting patientâ??s life at risk • History of good response in the past • Patient not responding to adequate trial of an antipsychotic medication • Augmentation of partial response to antipsychotic medication • Clozapine resistant schizophrenia • Not able to tolerate antipsychotic medications 5. Patients giving written informed consent for ECT and the study
Exclusion criteria
Exclusion criteria: 1. Co-morbid neurological or other psychiatric disorder (current or in past). 2. Patient with co morbid substance dependence or abuse in last 6 months, except nicotine and caffeine. 3. Subjects who have received ECT in past 6 months. 4. Baseline score of less than 24 on Mini Mental Status Examination (MMSE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome of the study is to study the cognitive side effect of ultrabrief pulse and brief pulse ECT as measured by Montreal Cognitive Assessment (MoCATimepoint: after 1-2days of first and eighth session of ECT. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are the clinical improvement in patients with schizophrenia as recorded on The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and overall severity score on Clinical Global Impression-Severity Index (CGI-SI) and changes in Neuron- specific enolase level as measured by ELISATimepoint: after 1-2days of first and eighth session of ECT. | — |
Countries
India
Contacts
Public ContactPRANJAL DEY
Central Institute Of Psychiatry
Outcome results
None listed