Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: DEXMEDETOMIDINE: DEXMEDETOMIDINE GROUP WILL RECEIVE AN INFUSION OF 0.4 MCG/KG/HOUR AFTER A BOLUS OF 0.5MCG/KG INTRAOPERATIVELY AND UPTO 24 HOURS IN THE POST OPERATIVE PERIOD APRT FROM T
Sponsors
AIIMS BHUBANESWAR
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria will be all patients within 19 to 70 years of age in either sex presenting to this hospital with diagnosis of aneurysmal SAH by clinical and radiological investigations planned for surgical clipping.
Exclusion criteria
Exclusion criteria: 1) Hemodynamic instability (SBP Heart failure class III or IV (New York Heart Association) 2) Renal failure 3) Liver failure (serum protein 5 mg/dL 4) Known or suspected brain death 5) Pregnancy 6) Unable to receive dexmedetomidine within 4 hours of surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Levels of apoptotic markers( caspase 3) at 24 hours in the postoperative periodTimepoint: 24 HOURS IN THE POSTOPERATIVE PERIOD | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Neurological outcomes in terms of Glasgow outcome scale at the time of discharge 2) Cognition function at the time of discharge in terms of MMSE Timepoint: TIME OF DISCHARGE ( when the clinician feels fit to dicahrge from hospital ) 1 week to 4 weeks | — |
Countries
India
Contacts
Public ContactNitasha Mishra
AIIMS, Bhubaneswar
Outcome results
None listed