comparison of pain and antibacterial efficacy of three different intracanal medicaments

Comparative Evaluation of the Antibacterial Efficacy and Postoperative Pain of Calcium Hydroxide Paste Combined with Ketorolac or Ciprofloxacin in Infected Root Canals with Asymptomatic Apical Periodontitis: A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/034753

Enrollment

Registered

2021-07-12

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis Health Condition 2: R688- Other general symptoms and signs

Interventions

Intervention1: calcium hydroxide: 1st group of the patient given calcium hydroxide intracanal medicament Intervention2: Calcium hydroxide with ketorolac: 2nd group of patients given Calcium hydroxide

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient age :25-65 years 2.Asymptomatic apical periodontitis. 3.Teeth with necrotic pulp that will be confirmed by pulp sensitivity test. 4.Periapical lesion with a periapical index score of 3,4 or 5.

Exclusion criteria

Exclusion criteria: 1.In patient where tooth is un restorable, inadequate length, poor periodontal status. 2.Patients who had received NSAIDS or antibiotic treatment in three months before the study. 3.Patient who had and systemic disease 4.Patient allergic to ketorolac and ciprofloxacin

Design outcomes

Primary

Measure	Time frame
pain Reduction in total microbial count and concentration of E fecalis in root canalTimepoint: 6 hrs, 12hrs, 24hrs, 48hrs, 72 hrs, 1 week	—

Secondary

Measure	Time frame
evaluation of periapical healingTimepoint: 3 months, 6 months, 9 months,12 months	—

Countries

India

Contacts

Public ContactDR MANDEEP S GREWAL

Faculty of Dental Sciences, SGT University, Gurugram, Haryana

drashthaarya@yahoo.co.in9810761757

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026