Health Condition 1: G96- Other disorders of central nervoussystem
Conditions
Interventions
None listed
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: All patients who need sedation to undergo brain MRI, aged between 5 and 60 years. Patients who will require both spine and brain MRI (with spine pathology). Patients receiving sedation for 20 to 60 minutes duration.Â
Exclusion criteria
Exclusion criteria: Refusal to provide informed consent Patients with identified causes of delayed waking up like hypothyroidism, hyponatremia Na ( 145 mEq/L [9], hypo/hyperglycemia, hypothermia with axillary temperature Patients with known liver and/or renal dysfunction. (Defined as elevated or aspartate amino-transferase/ alanine amino-transferase > 5 times [10] when reports are available, serum creatinine >1.2 mg/dL) [11] Patients on inotropic support. Patients who are intubated. Patients with motor component of Glasgow Coma Scale (GCS) Patients post intracranial surgeries/ resection surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of recovery is made without any stimulation (tactile or noxious). Time to spontaneous eye opening and limb movement by the patients will be recorded from the time of stoppage of infusion. The hippocampal volume will be calculated bilaterally in pre-contrast-volumetric MPRAGE sequence of brain imaging by the radiologist using Statistical Parametric Mapping. Timepoint: 0, 5, 7, 9â?¦.. minutes from the stoppage of infusion ( i.e., 5 minutes after stoppage of the infusion, and every 2 minutes up to a point where the patient becomes fit for discharge ) | — |
Secondary
| Measure | Time frame |
|---|---|
| assessment of adequacy to discharge will be assessed as per the Modified Aldrete Score which tests the activity level at request.Timepoint: 0, 5, 7, 9â?¦.. minutes from the stoppage of infusion ( i.e., 5 minutes after stoppage of the infusion, and every 2 minutes up to a point where the patient becomes fit for discharge ) | — |
Countries
India
Contacts
Public ContactNavyashree KS
National Institute of Mental Health and Neurosciences
Outcome results
None listed