Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: Effect of intravenous vitamin B12 on postoperative analgesia: Intravenous vitamin B12 1000micrograms in 100ml normal saline over 30minutes will be administered before induction of anaes
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: 1.Female patients aged 18 to 65 years scheduled for modified radical mastectomy under general anaesthesia. 2. Patients of American Society of Anesthesiologists(ASA) physical status I,II,III
Exclusion criteria
Exclusion criteria: 1.Patients with hepatic, renal, cardiac, endocrine, psychiatric and neurological disorders. 2. Patients with history of allergy to study drug. 3. Patients who received chemotherapy prior to surgery. 4. Patients with chronic pain syndrome on treatment with long term opioids. 5. Patients who cannot understand or interpret VAS for pain assessment. 6. Patients unwilling to participate in the study. 7. Patients unable to give informed consent. 8. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Comparision of duration of analgesia between vitamin B12 group and control group 2. Comparision of total Tramadol consumption in 24hours postoperatively between vitamin b12 group and control groupTimepoint: Total Tramadol consumption in 24hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To assess the magnitude of pain by Visual Analogue Scale(VAS) at different points of time. 2. To assess the sedation level using Ramsay sedation score 3. To observe adverse events during study period.Timepoint: T1-30minutes T2-1hour T3-2hours T4-4hours T5-6hours T6-24hours | — |
Countries
India
Contacts
Public ContactDr P Hemalatha
SRI VENKATESWARA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed