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EFFICACY OF HIGH FREQUENCY TRANSCRANIAL RANDOM NOISE STIMULATION ON fMRI AND CRAVING IN PATIENTS WITH ALCOHOL DEPENDENCE SYNDROME â??: A RANDOMIZED CONTROLLED TRIAL STUDY

EFFICACY OF HIGH FREQUENCY TRANSCRANIAL RANDOM NOISE STIMULATION ON CUE RELATED fMRI BOLD ACTIVATION AND CRAVING IN PATIENTS WITH ALCOHOL DEPENDENCE SYNDROME â??: A RANDOMISED CONTROLLED TRIAL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/034601
Enrollment
40
Registered
2021-07-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F102- Alcohol dependence

Interventions

Intervention1: high frequency transcranial random noise stimulation: 10 sessions of active and sham tRNS will be given to the respective groups once a day for 14 days. A DC-Stimulator Plus device will

Sponsors

Central Institute of Psychiatry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients who are diagnosed with Alcohol Dependence Syndrome, active dependence as per ICD-10[DCR](WHO,1993). 2. Men aged between 18 to 60 years old 3. Patients abstinent from alcohol at least for 10 days 4. In stable clinical condition with no need for emergency care 5. Patients willing to give informed consent.

Exclusion criteria

Exclusion criteria: 1. Any other co-morbid substance dependence except nicotine and caffeine. 2. Participants with any co-morbid psychiatric disorder. 3. History of severe withdrawal e.g., convulsions or delirium tremens during abstinence. 4. Not willing to give informed consent. 5. Patient with presence of pacemaker or other electronic implant, metal or magnetic objects in the brain.

Design outcomes

Primary

MeasureTime frame
changes in ACQ scoreTimepoint: 0weeks, 2 weeks, 4 weeks—

Secondary

MeasureTime frame
1.Changes in the BOLD signal in specified brain areas. 2.Relationship of reduction in craving with demographic and clinical variables in alcohol dependent patient will be determined. Timepoint: 0 weeks, 2weeks , 4 weeks—

Countries

India

Contacts

Public ContactDr Aniruddha Mukherjee

Central Institute of Psychiatry

a.mukherjee46@gov.in9474413598

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026