The effectiveness of intravenous dexmeditomidine versus lignocaine on perioperative haemodynamics in patients undergoing laparoscopic cholecystectomy

Comparision of attenuation of haemodynamic response to pneumo peritoneum by either Dexmeditomidine or lignocaine infusion administered to patients undergoing laparoscopic cholecystectomy -A Prospective Randomized double blind trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/034595

Enrollment

Registered

2021-07-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K810- Acute cholecystitis

Interventions

Intervention1: Attenuation of haemodynamic response to pneumo peritoneum by giving dexmeditomidine or lignocaine: In Dexmeditomidine group patients will receive inj .dexmeditomidine @ 0.4 mcg/kg/hr

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists physical status I,II,III 2)Patients with age :20 TO 60 Years. 3) BMI 4)Patients undergoing elective laparoscopic cholecystectomy (non malignant) .

Exclusion criteria

Exclusion criteria: 1)Patients refusal 2)Patients with uncontrolled cardio respiratory, renal, hepatic or endocrine disease 3)Conversion of laparoscopic to open cholecystectomy 4)Patients with drains placed insitu. 5)Patients who are unable to perform VAS scale. 6)Surgical time exceeding 150 min. 7)Pregnant and lactating women. 8)Patients who are on Beta adrenergic blocker therapy.

Design outcomes

Primary

Measure	Time frame
To study the attenuation of blood pressure and heart rate response to pneumo peritoneum in patients undergoing laparoscopic cholecystectomyTimepoint: the first requirement of analgesic dose within 24 hours	—

Secondary

Measure	Time frame
To compare the post operative sedation score between two groups To assess and compare the Time to first request for analgesia post operatively.-defined as whenever the patient complains of pain or when visual analogue score Number of propofol boluses required peri operatively. Number of episodes of hypertension and hypotension peri operatively. Number of doses of atropine, ephedrine, phenyl ephrine required intra operatively. Timepoint: 15,30,60minutes,2,3,4hours	—

Measure

Time frame

To compare the post operative sedation score between two groups To assess and compare the Time to first request for analgesia post operatively.-defined as whenever the patient complains of pain or when visual analogue score Number of propofol boluses required peri operatively. Number of episodes of hypertension and hypotension peri operatively. Number of doses of atropine, ephedrine, phenyl ephrine required intra operatively. Timepoint: 15,30,60minutes,2,3,4hours

—

Countries

India

Contacts

Public ContactDr Hemanth Natham

SVIMS

hemanthn1973@gmail.com9440285634

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026