Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
None listed
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Critically ill cirrhotics undergoing continuous renal replacement therapy.
Exclusion criteria
Exclusion criteria: 1. Patients with age less than 18 years 2. Severe known cardiopulmonary disease (structural or valvular heart disease, coronary artery disease, COPD) 3. Pregnancy 4. Chronic kidney disease on hemodialysis 5. Extremely moribund patients with an expected life expectancy of less than 24 hours 6. Failure to give informed consent from family members. 7. Hemodynamic instability requiring very high dose of vasopressors. 8. Septic shock would be defined as clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP more than equals to 65 mm of Hg and having a serum lactate more than 2 mmol/L despite adequate volume resuscitation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of SVR from baseline by 20% or above 600 and decrease in vasopressors at 24 hours after CRRT initiationTimepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of dialysis associated complications (hypotension, bleeding, hypothermia, catheter-related blood stream infections would be recorded).Timepoint: 24 hours;Incidence of renal recoveryTimepoint: 24 hours;Lactate clearance after CRRT initiationTimepoint: 6,12 and 24 hours | — |
Countries
India
Contacts
Public ContactDr Rakhi Maiwall
Institute of Liver and Biliary Sciences
Outcome results
None listed