Health Condition 1: E038- Other specified hypothyroidism
Conditions
Interventions
Intervention1: Levothyroxine: Levothyroxine dose
Dose per day 11 add 13 multiply 1 for female and 2 for male and half of serum TSH
Intervention2: New formula based arm: Dose per day 11 add 13 multi
Sponsors
Principal Investigator
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age above 18 years and 2.Newly diagnosed with primary hypothyroidism (overt and subclinical hypothyroidism) 3.Treatment-na�¯ve (not started on thyroid hormone treatment)
Exclusion criteria
Exclusion criteria: 1.Pregnancy, 2.Central hypothyroidism, 3.Within two years of post-radiotherapy or radioiodine ablation, 4.Post total thyroidectomy cases, 5.Major co-morbidities, 6.Co-prescription of treatment known to affect thyroid hormone metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Euthyroidism at follow up We expect around 60 percent of the participants will achieve euthyroidism at first visit based on calculated doseTimepoint: follow up will be at 6-12 weeks after starting dose and each dose adjustment | — |
Secondary
| Measure | Time frame |
|---|---|
| To estmate the incidence of Iatrogenic thyrotoxicosis in both armsTimepoint: At the 1st follow-up between 4-8 weeks of starting levothyroxine | — |
Countries
India
Contacts
Public ContactRekha Singh
All India Institute of Medical Sciences Bhopal
Outcome results
None listed