Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: standard care and amphotericin B: Standard of care+ Intervention- Intranasal amphotericin B preparation, Patient advised to instil dilute amphotericin nasal drops into both nostrils 3 t
Sponsors
Department of ENT
Eligibility
Inclusion criteria
Inclusion criteria: - pre-existing diabetes mellitus at the time of admission - in those without diagnosed diabetes at baseline, a fasting or random blood glucose level > 200 mg/ dl at any time point during admission - patients who have received >=6 mg/day of Dexamethasone or >=30mg/day of methylprednisolone - patients receiving immunomodulators for at least 24 hours - patients receiving systemic anti-bacterial drugs - patients with hematologic malignancies - receiving bone marrow transplant/ systemic chemotherapy/ HIV-AIDS/ immunosuppressive therapy after organ transplant
Exclusion criteria
Exclusion criteria: 1. COVID 19 patients with evidence of mucor mycosis at screening or randomization 2. COVID 19patients with features of invasive fungal sinusitis at screening or randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of COVID positive patients at risk for invasive fungal sinusitis developing mucor mycosisTimepoint: 14 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of COVID positive patients at risk for invasive fungal sinusitis developing mucor mycosisTimepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Pratibha C B
St Johns Medical College Hospital
Outcome results
None listed