Health Condition 1: K769- Liver disease, unspecified Health Condition 2: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Consecutive patients with cirrhosis or ACLF undergoing their first session of dialysis.
Exclusion criteria
Exclusion criteria: 1) Age 75 years 2) HCC 3) Recent history of blood product transfusion in the last 7 days 4) History of antiplatelets, antifibrinolytics or antithrombotics 5) Active untreated Sepsis/DIC 6) Any evidence of active bleed secondary to coagulopathy 7) Pregnancy 8) Comorbidities associated with poor outcome (Extrahepatic neoplasia, severe cardiopulmonary disease defined by a New York Heart Association score >3, or oxygen/steroid-dependent chronic obstructive pulmonary disease ) 9) Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dialysis related bleeding in first 24 hoursTimepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospital or ICU stayTimepoint: 7 days;Incidence of infectionsTimepoint: 24 hours;Incidence of infections and bleedingTimepoint: 7 days;Incidence of transfusion associated lung injury and circulatory overloadTimepoint: 24 hours;MortaliyTimepoint: 7 days;To assess correlation of ROTEM abnormalities with risk of clinically significant bleedingTimepoint: 7 days;To assess the need and volume of FFP, Cryoprecipitate, platelet and packed red blood cell transfusion based on ROTEM pre- and post-procedureTimepoint: 7 days | — |
Countries
India
Contacts
Public ContactDr Manoj Kumar Sharma
Institute of Liver and Biliary Sciences
Outcome results
None listed