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A study to compare two drugs Dexmedetomidine and Lignocaine to bring down blood pressure, pulse rate, respiratory rate and airway response to endotracheal extubation after CABG(Coronary Artery Bypass Graft) surgery.

A comparative evaluation of efficacy of Lignocaine and Dexmedetomidine to attenuate Hemodynamic and Airway response to endotracheal extubation in elective post operative CABG surgery: A prospective randomized control trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/034534
Enrollment
70
Registered
2021-07-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I259- Chronic ischemic heart disease, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: 0.5 mcg/kg diluted in 10 ml NS given over 60seconds, 5 minute before extubation Control Intervention1: lignocaine: 1.5mg/kg diluted in 10ml NS given over 60seconds, 5mi

Sponsors

INDIRA GANDHI INSTITUTE OF MEDICAL SCIENCES PATNA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: (1)ASA 2 and 3 (2)Patient undergoing elective CABG Surgery (3)Mallampati grade 1 and 2

Exclusion criteria

Exclusion criteria: (1)Allergy to studied drug (2)Patient with significant valvular heart disease (3)Patient with significant bradycardia

Design outcomes

Primary

MeasureTime frame
To assess the hemodynamic parameter and airway responseTimepoint: 1,3,5,7 minutes after drug administration 1,3,5,10,15,20 minutes after extubation—

Secondary

MeasureTime frame
To assess sedation status of patient and Airway response in form of coughing brochospadm and laryngospasmTimepoint: At extubation and 1,3,5,10,15,20 minutes after extubation—

Countries

India

Contacts

Public ContactDr Arvind Kumar

IGIMS, Patna

mithileshpmc2k10@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026