Health Condition 1: O- Medical and Surgical Health Condition 2: 8- Other Procedures
Conditions
Interventions
Intervention1: Intrathecal dexmedetomidine three different doses with hyperbaric Bupivacaine: Thirty patients per group were randomly allocated using sealed envelope technique into three groups namely
Sponsors
Shri Ram Murti Smarak Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Ninety patients belonging to ASA physical status I/II, aged 18-60 years of either sex, undergoing elective lower abdominal and lower limb surgeries under planned Subarachnoid Block (SAB).
Exclusion criteria
Exclusion criteria: Exclusion criteria included patient refusal, contraindication to SAB, hypersensitivity to the drugs being evaluated, Body Mass Index (BMI) more than 40 kg/m2, pregnancy, significant comorbid conditions like uncontrolled hypertension, congestive heart failure, myocardial infarction in the past 6 months, heart block, fixed cardiac output lesions. Cases that needed intraoperative conversion to general anesthesia were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective was to ascertain a safe IT dexmedetomidine dose for patients undergoing elective lower abdominal and lower limb surgeries and to analyze sensory and motor characteristics with drug combinations being evaluated by comparing duration of the spinal sensory blockade, onset of the sensory and motor blockadeTimepoint: Onset of sensory blockade shall be defined as the time taken from the drug injection to the time to reach T10 level and the offset of sensory block shall be presumed when pin prick sensation at S1 dermatome has returned. Duration of sensory block will be defined as the time interval elapsed between onset of sensory block at T10 to regression of sensory block to S1. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures included level of sedation, comparison of hemodynamic variables and complications, if any.Timepoint: HR, NIBP(systolic , diastolic and mean NIBP) ,SpO2 will be monitored continuously during the course of surgery and data will be recorded at 5 minutes interval for first 20 minutes then at 15 minutes interval till end of first hour, then at 30 minutes interval for next one hour, hourly for further 2 hours, followed by 4 hourly till completion of 24 hrs | — |
Countries
India
Contacts
Public ContactDr Ashita Mowar
Shri Ram Murti Smarak Institute of Medical Sciences
Outcome results
None listed