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Early detection of cardiotoxicity by global longitudinal strain (2D ECHO) and serum biomarkers in lymphoma patients on chemotherapy.

Evaluation of cardiotoxicity using global longitudinal strain (GLS)by 2D speckle tracking echocardiography of left ventricle and serum cardiac biomarkers in lymphoma patients on anthracycline based chemotheraoy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/07/034518
Enrollment
28
Registered
2021-07-01
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C833- Diffuse large B-cell lymphoma Health Condition 2: C820- Follicular lymphoma grade I Health Condition 3: C821- Follicular lymphoma grade II Health Condition 4: C823- Follicular lymphoma grade IIIa Health Condition 5: C824- Follicular lymphoma grade IIIb Health Condition 6: C813- Lymphocyte depleted Hodgkin lymphoma Health Condition 7: C814- Lymphocyte-rich Hodgkin lymphoma Health Condition 8: C812- Mixed cellularity Hodgkin lymphoma Health Condition 9: C810- Nodu

Interventions

None listed

Sponsors

PGIMERChandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. newly diagnosed patients of lymphoma planned for chemotherapy. 2. age equal to or more than 14 years.

Exclusion criteria

Exclusion criteria: 1. LVEF less than 50 %. 2. Suboptimal echocardiographic images. 3. CKD stage IV and V.

Design outcomes

Primary

MeasureTime frame
1. To estimate cardiotoxicity. 2. To estimate subclinical cardiotoxicity. Timepoint: At baseline, after 3 chemo cycles, after end of chemotherapy

Secondary

MeasureTime frame
To estimate change in levels of Troponin-T and NT-pro BNP from baseline. To identify risk factors associated with cardiotoxicity. Timepoint: at baseline ,after 3 chemotherapy cycles, after end of chemotherapy .

Countries

India

Contacts

Public ContactDr Lucky kumar

Post Graduate Institute of Medical Education and Research, Chandigarh.

rajeshvijay999@hotmail.com9815221856

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 6, 2026