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A study to compare the effect of Dexmedetomidine and Lignocaine in preventing Etomidate-induced Myoclonus

Comparison on the effect of Dexmedetomidine and Lignocaine in the prevention of Etomidate-induced Myoclonus - A Randomized Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034499
Enrollment
104
Registered
2021-06-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Intravenous Dexmedetomidine: 0.5microg/kg of Dexmedetomidine IV over 5 minutes, given 2 minutes before induction with 0.3mg/kg of Etomidate Intervention2: Intravenous Lignocaine: 1mg/kg

Sponsors

Shammy N
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II Patients willing to participate

Exclusion criteria

Exclusion criteria: 1. Bradycardia 2. Upper respiratory tract infection 2 weeks before surgery 3. History of allergy to study drugs (Dexmedetomidine, Lignocaine, Etomidate) 4. Diabetes Mellitus, Hypertension, Cardiovascular, Respiratory and Neurologic disease 5. Adrenocortical dysfunction 6. Morbid obesity 7. Emergency surgery patients 8. Received sedatives, analgesics or opioids within 24 hours prior to surgery 9. Communication problems

Design outcomes

Primary

MeasureTime frame
Incidence of MyoclonusTimepoint: 90 seconds—

Secondary

MeasureTime frame
NilTimepoint: Nil—

Countries

India

Contacts

Public ContactProf Dr Gojendra Rajkumar

Regional Institute of Medical Sciences, Imphal, Manipur

gojendrar68@gmail.com9862824562

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026