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Management of spinal induced hypotension in caesarean section using bolus doses of Norepinephrine or Phenylephrine

Norepinephrine and phenylephrine boluses for the management of spinal anaesthesia induced hypotension in caesarean section - a comparative trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034490
Enrollment
70
Registered
2021-06-30
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INTRAVENOUS PHENYLEPHRINE: Patients will receive Phenylephrine 50 µg/ml as an intravenous bolus whenever the systolic arterial pressure dropped below 20% of baseline Control Interventio

Sponsors

Andrea Nongsiej
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with ASA physical grade I or II 2. Patients willing to give written informed consent

Exclusion criteria

Exclusion criteria: 1. History of allergy to local anaesthetic agent and/or drugs 2. Bleeding disorders like Von Willebrand disease, ITP, platelet count 14 seconds, INR >1.5, other obstetric omplications associated with coagulopathy (placental abruption, pre eclampsia) 3. Local site infection 4. Spinal deformity 5. Cardiac, respiratory diseases and kidney disorder, neurological deficit

Design outcomes

Primary

MeasureTime frame
To compare the number of intravenous bolus doses of norepinephrine or phenylephrine required to treat spinal hypotension Timepoint: The outcome will be assessed at baseline, 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes, then every 5 minutes till the end of the surgery—

Secondary

MeasureTime frame
To compare the incidence of bradycardia, hypertension, nausea and vomiting in mother and foetal outcomes such as Apgar score and umbilical vein blood gases. Timepoint: The outcome will be assessed at baseline, 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes, then every 5 minutes till the end of the surgery—

Countries

India

Contacts

Public ContactDr T Hemjit Singh

REGIONAL INSTITUTE OF MEDICAL SCIENCES

takhelhem@yahoo.com9436021445

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026