Health Condition 1: G92- Toxic encephalopathy
Conditions
Interventions
Intervention1: nil: nil
Intervention2: NIL: NIL
Control Intervention1: nil: nil
Control Intervention2: NIL: NIL
Sponsors
Department of Pediatrics PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1)Postmenstrual age between 28 weeks and 44 weeks. 2)Having either proven (culture-positive) or probable sepsis (positive septic screen). 3)The neonates have encephalopathy as a part of sepsis syndrome.
Exclusion criteria
Exclusion criteria: Neonates with lethal congenital malformations. Moribund neonate who is likely to die in next 6 hours, as perceived by treating team. Neonates having unhealthy skin precluding the placement of sensors. New born with severe birth asphyxia defined as 1-minute APGAR Score ⩽3 and/or with clinically defined moderate to severe encephalopathy as a result of antenatal/intrapartum or postnatal asphyxia. Neonates having congenital hydrocephalus, intracranial malformations, neuronal migration disorders, bilirubin encephalopathy. Suspected or proven Inborn errors of metabolism Consent refused by the parents of the neonates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| .To study the prevalence and patterns of abnormal aEEG among neonates with sepsis associated encephalopathy. 2. To find the association between abnormal aEEG patterns and abnormal neurological examination at the time of discharge from hospital. Timepoint: From EEG monitoring for 12-24 hrs till at the time of discharge from hospital. | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence rate of abnormal background patterns, incidence rate of seizures, incidence rate of abnormal sleep wake cyclingTimepoint: baseline,at the time of discharge. | — |
Countries
India
Contacts
Public ContactShiv Sajan Saini
Department of Pediatrics , PGIMER Chandigarh
Outcome results
None listed