Health Condition 1: I061- Rheumatic aortic insufficiency Health Condition 2: I060- Rheumatic aortic stenosis Health Condition 3: I051- Rheumatic mitral insufficiency Health Condition 4: I050- Rheumatic mitral stenosis
Conditions
Interventions
None listed
Sponsors
Rajiv Gandhi University of Health Sciences
Eligibility
Inclusion criteria
Inclusion criteria: All patients irrespective of their age or sex with rheumatic heart disease (AS/AR or MS/MR) diagnosed by clinical history and echocardiography.
Exclusion criteria
Exclusion criteria: 1.Patients who have prosthetic valves that cause susceptibility artifacts and degrade the accuracy of CMR assessment. 2.Patients with previously repaired valves. 3.Patient with active rheumatic carditis and decompensated heart failure. 4.Patients with congenital valve pathologies. 5.Patients with coronary artery disease. 6.Patients who did not complete the study due to any patient-related factors and loss to follow up. 7.Poor-quality scans due to patient-related or technical factors. 8.Patient with contraindications to CMR.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To determine the proportion of Rheumatic heart disease (RHD) patients with myocardial fibrosis using late gadolinium enhancement(LGE) across mitral and aortic valvular pathologies in RHD patients. 2.To describe the proportions of various LGE patterns across mitral and aortic valvular pathologies in RHD patients. 3.To determine the association between myocardial fibrosis measured by LGE and post-operative biventricular remodeling and function as determined by post-operative cardiac MRI. Timepoint: 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of association between left ventricle (LV) and right ventricle (RV) dysfunction in single mitral or aortic valvular and multi valvular involvement in RHD patients.Timepoint: 18 months | — |
Countries
India
Contacts
Public ContactHazif Backer P
Sri Jayadeva Institute of Cardiovascular Sciences and Research
Outcome results
None listed