Health Condition 1: O169- Unspecified maternal hypertension,unspecified trimester
Conditions
Interventions
Intervention1: Metformin: Participants belonging to group 1 will be given metformin (500 mg) tab twice daily from first trimester till delivery
Control Intervention1: Multivitamin tablet: Participants
Sponsors
IPGMER
Eligibility
Inclusion criteria
Inclusion criteria: Pregnant woman with 1) previous history of preeclampsia or gestational hypertension 2) Primigravida 3) Obesity (BMI >35) 4) Patient of diabetes 5) pregnancy interval of more than 10 years 6) family history of pre-eclampsia 7) multi-fetal pregnancy 8) high gestational age ( > 40 years) at presentation 10)pre-existing vascular disease 11) pre-existing kidney disease(including chronic kidney patient with GFR above 50 ml/min) 12) pregnant mothers who will come for their first visit in first trimester
Exclusion criteria
Exclusion criteria: PATIENTS ALREADY ON METFORMIN PATIENTS OF CKD STAGE 3 OR ABOVE PATIENTS TAKING METFORMIN FOR TREATMENT OF PCOS PATIENTS OF CHRONIC HYPERTENSION KNOWN HYPERSENSITIVITY TO METFORMIN
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure more than or equal to 140 mm Hg and/ or diastolic blood pressure more than or equal to 90 mm HgTimepoint: 20 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal death Eclampsia Pulmonary oedema Severe renal impairment or the need for dialysis Cerebral vascular event Liver haematoma or rupture Placental abruption Congenital malformation of newborns Hypoglycemia in newborn (blood glucose less than 30 mg% in first 24 hours)Timepoint: second and third trimester, after delivery | — |
Countries
India
Contacts
Public ContactAnuradha Ghosh
IPGMER
Outcome results
None listed