Health Condition 1: H00-H59- Diseases of the eye and adnexa
Conditions
Interventions
Intervention1: Nepafenac 0.1% Ophthalmic Suspension: Nepafenac 0.1% eye drops
Dosage- 1 drop QID for 6 months
Control Intervention1: Carboxy-methylcellulose sodium lubricant eye drops 0.5%w/v: Carboxy
Sponsors
Hyderabad Eye Research Foundation
Eligibility
Inclusion criteria
Inclusion criteria: -Children upto 9 years of age diagnosed with CHED (Congenital Hereditary Endothelial Dystrophy) with bilaterally equal corneal involvement -Patients agreeing on a regular monthly follow-up for a minimum of 6 months
Exclusion criteria
Exclusion criteria: 1. Patients undergone eye surgery (PK,DSEK,DMEK, Glaucoma surgery, etc) 2. Patient with eye pathologies like-glaucoma,dry eye,nystagmus,cataract,corneal ulcer,reduced corneal sensations,etc 3. Not able to come for follow up 4.Asymmetrical corneal involvement 5.Allergy to the drug 6. Patients with asthma or bleeding dyscrasias 7. Non-cooperative children
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Clinical change in the corneal transparency in the patients with CHED (slitlamp) 2.Change in the corneal transparency on Densitometry in the patients with CHED (Oculyzer machine)Timepoint: Measured at each monthly follow-up till study completion | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in visual acuity in patients of CHED (Subjective Refraction) 2. Change in the Corneal thickness Pachymetry/ Anterior Segment OCT (Optical Coherence Tomography) readings at each visitTimepoint: Measured at each monthly follow-up till study completion | — |
Countries
India
Contacts
Public ContactNeet Mehta
L V Prasad Eye Institute
Outcome results
None listed