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Treatment of gum disease using Rosuvastatin or Simvastatin gel.

AN EXPLORATORY COMPARATIVE STUDY OF THE EFFICACY OF LOCALLY DELIVERED 1.2% ROSUVASTATIN AND 1.2% SIMVASTATIN GEL AS AN ADJUNCT TO NON SURGICAL PERIODONTAL THERAPY IN CHRONIC PERIODONTITIS: A CLINICAL AND MICROBIOLOGICAL ASSAY.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034343
Enrollment
60
Registered
2021-06-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 1.2% Rosuvastatin gel : Statins, inhibitors of 3-hydroxy-3-glutaryl-coenzyme A reductase ( HMG-CoA reductase), are a group of drugs used primarily to treat hyperlipidemia and cardiovasc

Sponsors

Panineeya Institute of Dental Sciences and Research centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Probing pocket depth (PPD) 5-7mm Patients who have not received periodontal therapy, within preceding 6 months. .

Exclusion criteria

Exclusion criteria: Patients who received treatment with antibiotics/anti-inflammatory drugs in last 3 months. Pregnant and lactating females. Medically compromised patients. Smokers, tobacco chewers and alcoholics. Patients who were allergic to drugs. Severe form of Periodontics with deep pockets.

Design outcomes

Primary

MeasureTime frame
â??Plaque index (Silness and Loe, 1964) â??Modified gingival index ( Lobene et al, 1986) â??Sulcus bleeding index â?? (Muhlemann and Son, 1971) â??Probing pocket depth â??Clinical Attachment Loss (CAL) Timepoint: 6 weeks and 3 months—

Secondary

MeasureTime frame
Presence of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.Timepoint: 6 weeks—

Countries

India

Contacts

Public ContactDr G Hima Bindu

Panineeya Institute of Dental Sciences and Research centre

bindurakasi@gmail.com9959200225

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026