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The effect of intracuff air vs. 1% propofol on intraoperative haemodynamics and throat morbidity in general anesthesia

The effect of intracuff air, 0.9% normal saline, 4% lignocaine or 1% propofol on intraoperative hemodynamics and its laryngotracheal morbidity after tracheal extubation. - ETTCP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034323
Enrollment
120
Registered
2021-06-21
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Air: Inflation of cuff of Endotrachial tube with 6 ml air in General Anesthesia for duration 60-180 minutes Control Intervention1: Propofol, 4% Loxicard, 0.9% Saline: Inflation of ETT c

Sponsors

Self Sponsored
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA CLASS I/II. Age >=18 to 65 years maintaining a neutral position of the head and the neck No known laryngeal or tracheal defects Scheduled for elective Sx below neck under general anesthesia with endotracheal intubation Surgery duration of 60â??180 min BMI >30 Kg/m2 Patients giving written & informed consent

Exclusion criteria

Exclusion criteria: Patients with any neurological or psychiatric disorder, History of smoking, laryngotracheal diseases, Severe cardiovascular or respiratory disease, History of URTI within the last 10 days prior to the operation, Morbid obesity, allergies to anesthetic agents to be used, alcohol or drug addiction, Lung complications such as chronic obstructive pulmonary disease (COPD) Patients with a history of malignant hypothermia Surgery less than 60 min and longer than 180 min, Surgery in the Trendelenburg and Reverse Trendelenburg position, Nasogastric tube in situ, oropharyngeal airway introduced perioperative, Unsuccessful intubation in one attempt owing to unexpected complications with intubation, History of increased ICP, Intra Ocular Pressure, Ischemic Heart Disease. Patients with full stomach, history of gastric regurgitation, requiring rapid sequence induction, with anticipated difficult airway, Patients undergoing laparoscopic surgeries Cormack Lehane scores 3 and 4 Absolute contraindication to the study drug.

Design outcomes

Primary

MeasureTime frame
Our primary aim is to assess the intraoperative hemodynamic such as (HR, SBP, DBP MAP) of the patient on cuff inflation with different media.Timepoint: Every 15 Minutes—

Secondary

MeasureTime frame
Secondary aim include postoperative coughing, and laryngotracheal morbidity measured in terms of sore throat, dysphagia, and hoarseness of voice.Timepoint: Every 15 Minutes—

Countries

India

Contacts

Public ContactDr Priyamvada Gupta

Mahatma Gandhi University of Medical Science and Technology

drpriyamvada@hotmail.co.uk9413418336

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026