To compare hemodynamic response in laparoscopic surgeries after administering different doses of oral clonidine.

Efficacy of different doses of oral clonidine as premedication in attenuating haemodynamic response to pneumoperitoneum during laparoscopic surgeries.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/06/034319

Enrollment

Registered

2021-06-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Group C 50: single dose of tablet clonidine 50 mcg given orally, 90 mins before surgery. Control Intervention1: Group C 100: single dose of tablet clonidine 100 mcg given orally, 90 min

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grades I or II 2. Either gender 3. Adult patients aged > 18 years and 4. Scheduled for laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: 1. Patients not willing to give consent 2. Patients allergic to clonidine 3. Patient with concomitant use of monoamine oxidase inhibitors, tricyclic antidepressants or opioids 4. Pregnant females 5. Patients who are chronic hypotensive.

Design outcomes

Primary

Measure	Time frame
To compare and evaluate pneumoperitoneum induced haemodynamic changes after administering oral clonidine at different doses as premedication with respect to the following: 1) Heart Rate (HR) 2) Systolic Bp (SBP) 3) Diastolic BP (DBP) 4) Mean arterial blood pressure (MAP) 5) End tidal cabon di-oxide (EtCo2) 6) EntropyTimepoint: Vitals measured at various time interval: Baseline After premedication Before induction 2 minutes after Endotracheal tube intubation time in minutes after insufflation (AI): AI 1 AI 5 AI 15 AI 30 AI 45 AI 60 Exsufflation After extubation	—

Measure

Time frame

To compare and evaluate pneumoperitoneum induced haemodynamic changes after administering oral clonidine at different doses as premedication with respect to the following: 1) Heart Rate (HR) 2) Systolic Bp (SBP) 3) Diastolic BP (DBP) 4) Mean arterial blood pressure (MAP) 5) End tidal cabon di-oxide (EtCo2) 6) EntropyTimepoint: Vitals measured at various time interval: Baseline After premedication Before induction 2 minutes after Endotracheal tube intubation time in minutes after insufflation (AI): AI 1 AI 5 AI 15 AI 30 AI 45 AI 60 Exsufflation After extubation

—

Secondary

Measure	Time frame
1. Preoperative anxiety scores 2. Use of additional opioids intraoperatively 3. Post-operative nausea, vomiting and shivering in the first 2 hours, postoperatively 4. To compare post-operative sedation in the first 2 hours 5. Awareness using entropy Timepoint: number of episodes of sedation and post operative nausea and vomiting for 2 hours post surgery	—

Countries

India

Contacts

Public ContactDr Juhi Sharma

Kasturba medical college

shajimanipal@yahoo.co.in9449388791

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026