Health Condition 1: C56- Malignant neoplasm of ovary
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Chittaranjan National Cancer Institute
KolGOTrg
Eligibility
Inclusion criteria
Inclusion criteria: a) All non-mucinous epithelial ovarian cancer irrespective of their age b) All first degree and second degree relatives of women diagnosed with epithelial ovarian cancer and found to have deleterious mutation in BRCA1 or 2 c) If further funding is available: Then testing according to the NCCN guidelines for Hereditary Breast and Ovarian cancer risk assessment 1. Personal history of breast cancer and â?¥1 of these: ï?· Diagnosed at age â?¤45 years ï?· Diagnosed at age â?¥50 years with â?¥1 close blood relatives with breast cancer at age 50 years and/or â?¥1 close blood relatives with epithelial ovarian cancer at any age ï?· 2 breast primaries when first breast cancer diagnosis occurred at age â?¤50 years ï?· Diagnosed at age â?¤60 years with a triple negative breast cancer ï?· Diagnosed at age â?¤50 years with a limited family history ï?· Diagnosed at any age with â?¥2 close blood relatives with pancreatic cancer at any age Close male blood relative with breast cancer Individual of ethnicity associated with higher mutation frequency (e.g., Ashkenazi Jewish) Personal history of epithelial ovarian cancer ï?· Personal history of male breast cancer Personal history of pancreatic cancer at any age with â?¥2 close blood relatives with breast and/or ovarian cancer and/or pancreatic cancer at any age 2. No personal history of breast cancer, but â?¥1 of these: ï?· First- or second-degree blood relative meeting any of the above criteria Third-degree blood relative with breast cancer and/or ovarian cancer with â?¥2 close blood relatives with breast cancer (â?¥1 with breast cancer at age â?¤50 years) and/or ovarian cancer
Exclusion criteria
Exclusion criteria: Any patient who does not meet the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify whether implementation of nurse led genetic clinic supported by patient public involvement is cost-effective Identifying more individuals at risk of cancers through awareness and screening campaigns. Improving the uptake of genetic testing and referrals. In the longer term, reduction in women being diagnosed with advanced breast-ovarian cancers in a defined geographical area 5. Economic analysis of such approach where the cost of facility is part-borne by local communityTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess acceptability and embeddedness (population/ provider/governmental level) Timepoint: 2 years;Compare local community satisfaction (rates and qualitative) between screening camps facilitated and organized by PPI and local champions versus those organized by conventional institutional initiated effortsTimepoint: 2 years;Study willingness to pay (WTP) for screening and genetic testing in population attending the screening campsTimepoint: 2 years;Assessing differences in service implementation (barriers and solutions and risk/harm) for this model in rural versus urban and different socio-economic strata which would inform upscaling it within India and eventually to other LMICsTimepoint: 2 years;Evaluate the training programme of developing nurse genetic counsellors as measured by success of implementing a West Bengal Health University affiliated course of genetic counselling and interest/uptake of nursing and allied health care professionals in attending such coursesTimepoint: 2 years | — |
Countries
India, Nepal
Contacts
Public ContactDona Chakraborty
Chittaranjan National Cancer Institute
Outcome results
None listed