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needling with blood derived platelet concentrates to increase the thickness of gum tissue

Non surgical technique to increase the thickness of thin gingival phenotype using injectable platelt rich fibrin with or without microneedling- A randomised controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034264
Enrollment
36
Registered
2021-06-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K069- Disorder of gingiva and edentulousalveolar ridge, unspecified

Interventions

Intervention1: i-PRF with micro needling: Venous blood (5 ml) will be taken from the patient every session and i-PRF will be created in the centrifuge. i-PRF+ micro needle application will be injected

Sponsors

No funding from any agency
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Thin gingival phenotype –gingival thickness 2.Subjects with good general health. 3. Periodontally healthy subjects. (According to Consensus report of workgroup 1 of the 2017 World Workshop on the Classification Of Periodontal And Peri-Implant Diseases And Conditions.).

Exclusion criteria

Exclusion criteria: 1. Any systemic diseases known to contraindicate the procedure. 2. Subjects who is under any medication that is known to influence the thickness of gingiva example: anticonvulsants [phenytoin], immunosuppressant [cyclosporine A , calcium channel blockers[ amlodipine , nifidepine, verapamil, diltiazem] 3. Smokers 4. Subjects pregnancy and lactation. 5. History of periodontal surgery in the anterior mandible. 6. Active orthodontic treatment. 7. Crowding, and marginal tissue-recession in the anterior mandible region. 8. Subjects with clotting disorders and platelet dysfunction. 9. Missing, impacted tooth in the anterior region. 10. Teeth with prosthetic crowns or restorations in the anterior mandible region. 11. History of trauma in the anterior region. 12. Congenital & Developmental anomalies of Bone in anterior region.

Design outcomes

Primary

MeasureTime frame
Changes in the Gingival thickness will be measured using CBCT and transgingival probing using digital callipers in mm (precision of 0.01mm using digital calliper) measured at fixed point At baseline, one month, 3 months , 6 months.Timepoint: Changes in the Gingival thickness will be measured using CBCT and transgingival probing using digital callipers in mm (precision of 0.01mm using digital calliper) measured at fixed point At baseline, one month, 3 months , 6 months.—

Secondary

MeasureTime frame
1) Pocket Probing depth. 2) Clinical attachment level. 3) Keratinized tissue width.Timepoint: At baseline and 6 months—

Countries

India

Contacts

Public ContactPOOJITH K M

Government Dental college and Research Institute,B

periosmitha@gmail.com09449630572

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026