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Changes in gut microflora of neonates with pneumonia sepsis

Modulation of Neonatal gut microbiome in Pan resistant and sensitive Klebsiella pneumoniae sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/06/034251
Enrollment
30
Registered
2021-06-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P369- Bacterial sepsis of newborn, unspecified

Interventions

None listed

Sponsors

Manipal Center for Infectious Diseases MAC ID
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All neonates admitted to NICU. Informed consent from mother/family.

Exclusion criteria

Exclusion criteria: Surgical/chromosomal abnormalities. Culture negative sepsis Neonates with necrotizing enterocolitis prior to infection. Neonates requiring gastrointestinal surgeries. No informed consent given.

Design outcomes

Primary

MeasureTime frame
The gut microbial colonization pattern in infants with pan-drug resistant Klebsiella pneumoniae and pan drug-sensitive Klebsiella pneumoniae sepsis, to determine key insights into the onset of sepsis development, Impact, and recovery. The difference in neonates gut colonization pattern with pan-drug resistant Klebsiella pneumoniae and pan drug-sensitive Klebsiella pneumoniae sepsis. Effect of antimicrobial therapy on gut microbiota dysbiosis. Timepoint: Twelve months—

Secondary

MeasureTime frame
Effect of antimicrobial therapy on gut microbiota dysbiosis.Timepoint: Twelve months—

Countries

India

Contacts

Public ContactApurv Barche

Manipal Academy of Higher Education

apurv.barche@manipal.edu7470345111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026