Health Condition 1: G00-G99- Diseases of the nervous system
Conditions
Interventions
Intervention1: nil: nil
Control Intervention1: nil: nil
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Patients with GBS, based on clinical, CSF and electro-diagnostic criteria will be included in this study. GBS patients with clinical evidence (defined below) of sympathetic hyperactivity will receive prazosin and titrated as per patientâ??s requirement. clinical evidence of sympathetic hyperactivity includes cold and clammy skin (after ruling out dehydration), presence of hypertension (SBP > 140/90 mmHg) for more than 2 hours with or without pulmonary edema or Labile BP (defined as BP differences of >40mmHg in a single day) or Resting Tachycardia ( > 125 beats per minute) for 2 hours.
Exclusion criteria
Exclusion criteria: Patients with hypo or hyperkalemic paralysis, toxins, porphyria, viral myositis, MND, Cervical myelopathy and CSF cell > 50/mm3 will be excluded. GBS patients with Hypotension (systolic blood pressure < 90 mmHg) and bradycardia ( < 48 beats per minute) will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of patients with resolution of sympathetic hyperactivity (dysautonomia defined as 1. SBP/DBP 140/90 mmHg. 2. BP variability 20 mmHg 3. Pulse rate 90/min without bradycardia. 4. resolution of pulmonary edema and other clinical signs of sympathetic over-activityTimepoint: 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. time to resolution of sympathetic over-activity 2. patients developing adverse events to prazosin eg. hypotension, brady cardia etc. 3. disability at 1, 3 and 6 months assessed by Hughes disability scale. 4. proportion of patients succesfully completing 48 hour T-Piece trial. 5. proportion of patients with failed extubation. 6. spectrum of dysautonomia in GBS patients.Timepoint: 6 month | — |
Countries
India
Contacts
Public ContactDr Mritunjai Kumar
all india institute of medical sciences, Rishikesh
Outcome results
None listed