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To determine whether the change in blood pressure during head down position and transiently increasing breath volume can predict the response to fluid therapy in seriously ill patients on mechanical ventilator receiving low breath volume and in prone position during COVID pandemic

To determine whether the change in pulse pressure variation during Trendelenburg manoeuvre and â??Tidal volume challengeâ?? can predict fluid responsiveness in critically ill patients ventilated using low tidal volume and in prone position during COVID pandemic

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034183
Enrollment
40
Registered
2021-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome Health Condition 2: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 3: I959- Hypotension, unspecified Health Condition 4: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems Health Condition 5: J189- Pneumonia, unspecified organism Health Condition 6: J969- Respiratory failure, unspecified

Interventions

Intervention1: Trendelenburg test and tidal volume challenge test: The trendelenburg test is performed by moving the bed from 15 degree up position to near 15 degree down position. The change in pulse

Sponsors

Natesh Prabu R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (Age > 18 yrs ) Acute circulatory failure Receiving protective lung ventilation Need of prone ventilation as decided by treating physician.

Exclusion criteria

Exclusion criteria: Cardiac arrhythmias, Acute myocardial infarction Previously known significant valvular disease or intracardiac shunt Air leakage through chest drains Right heart failure An urgently required fluid challenge. Abdominal compartment syndrome, and pregnancy Raised intracranial hypertension

Design outcomes

Primary

MeasureTime frame
To determine whether the change in Pulse Pressure Variation during Trendelenburg manoeuvre in prone ventilation and â??tidal volume challengeâ?? can reliably predict fluid responsiveness in patients ventilated in prone position.Timepoint: baseline—

Secondary

MeasureTime frame
To determine whether non-invasive parameters like heart rate, blood pressure, Pulse pressure, ETCO2, Perfusion index change can reliably predict fluid responsiveness in patients during PLRT and during Trendelenburg manoeuvreTimepoint: immediate;To study the dynamic change in pulse pressure variation with different body positionsTimepoint: immediate—

Countries

India

Contacts

Public ContactNatesh Prabu R

St Johns Medical college hospital

drnateshrprabu@gmail.com08022065334

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026