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A study to show the effectiveness of giving a drug vasopressor before hand to prevent the fall in blood presssure following injection through lower back in cesarean sections.

Effectiveness of prophylactic norepinephrine infusion in preventing hypotension following spinal anaesthesia in caesarean section-a prospective, randomized, double blind study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/034138
Enrollment
100
Registered
2021-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 1- Obstetrics

Interventions

Intervention1: A BOLUS OF VASOPRESSOR NOREPINEPHRINE.: A bolus of 1 ml of norepinephrine prepared at the dosage of 6microgram /ml given in the direct IV access using the 3 way stop cock whenever the h

Sponsors

Office of principal Midnapore medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All ASA criteria I and II 2.The patients giving valid consent 3.Elective LSCS 4.Patients age 18 to 35 years 5.Term Singleton pregnancy

Exclusion criteria

Exclusion criteria: 1.Patientsâ?? refusal to take part in the study. 2.Patients with co-morbidity of cardiovascular system, respiratory system, Neurological and hepatic renal disorders. 3.Patients with contraindications to spinal anesthesia like local site infection, coagulation disorders. 4.Patients with obstetric complication like breech presentation,pregnancy induced hypertension, gestational diabetes mellitus,HELLP syndrome and other coagulation and auto immune disorders 5.Patients with neonatal compromise like fetal bradycardia , meconium stained liquor ,IUGR. 6.Failed spinal , repeat spinal , patchy spinal , conversion to General anesthesia at any moment of surgery is excluded from study. 7.Patient with history of allergy to study drugs. 8.Height 180cm. 9.Weight 100kg.

Design outcomes

Primary

MeasureTime frame
1.To monitor and record haemodynamic parameters like Systolic blood pressure,Diastolic blood pressure,Mean arterial pressure and heart rate at specified time intervals and compare between study. 2.To record the number of hypotension episodes in both groups.Timepoint: Non invasive BP monitoring started after intrathecal injection set at one minute time interval until delivery and followed by 3 minutes interval after delivery till the completion. The time of first episode of hypotension noted if it occurred

Secondary

MeasureTime frame
Incidence of Tachycardia, hypertension, bradycardia, intra operative nausea and vomiting, other complications and comparision of neonatal apgar scores and umbilical cord blood analysisTimepoint: 1 min interval from start of intraoperative period to baby delivery and 3 minutes intervals till end of operation. Apgar score will be taken at 1 minute and 5 minutes of baby delivery

Countries

India

Contacts

Public ContactDr Prosenjit Mukherjee

Midnapore medical college and hospital

bjoybnrjee@gmail.com9332132242

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026