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Role of mitochondrial gene polymorphisms in Gestational Diabetes Mellitus patients

Assessment of Serum Leptin levels and tRNALeu(UUR) gene and ND1 gene polymorphism in Gestational Diabetes Mellitus patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/06/034137
Enrollment
150
Registered
2021-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O244- Gestational diabetes mellitus

Interventions

None listed

Sponsors

Department of Biochemistry Maulana Azad Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: For Cases: Primigravida Diagnosed GDM patients based on DIPSI Criteria (Diabetes in Pregnancy Study Group India). For Controls: Non-GDM Primigravida pregnant subjects with normal glucose tolerance.

Exclusion criteria

Exclusion criteria: 1. Subjects with Hypothyroidism. 2. Subjects with Chronic inflammatory diseases. 3. Subjects with Type 1 or Type 2 Diabetes Mellitus. 4. Subjects with known mitochondrial dysfunction(s).

Design outcomes

Primary

MeasureTime frame
To establish an association between mtDNA mutations, GDM and leptin.Timepoint: Baseline: To establish an association between tRNALeu(UUR) gene and ND1 gene polymorphism, GDM and leptin.—

Secondary

MeasureTime frame
To understand role of mitochondria in pathophysiology of GDM.Timepoint: At baseline only: A positive association may link the role of mitochondrial gene polymorphisms and leptin in the pathophysiology of GDM.—

Countries

India

Contacts

Public ContactDr Harshit Kelkar

Department of Biochemistry, Maulana Azad Medical College

lchandra70@yahoo.com9873167313

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026