Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Pharmacological Intervention: Studying the effect of Propofol on diastolic function of left heart in patients undergoing surgery under general anaesthesia
2 mg per kg of propofol will be administered via Intravenous route over the span of 30 seconds
Control Intervention1: Pharmacological Intervention: Studying the effect of Etomidate on diastolic functi
0.3 mg per kg of Etomidate will be administered via Intravenous route over the span of 30 seconds
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients ( >18 years of age) with ASA PS 1 or 2 requiring surgery under general anaesthesia will be recruited in this study
Exclusion criteria
Exclusion criteria: Patients with pre-existing cardiac lesions will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the changes in E/e prime between the groupsTimepoint: After administration of the study drug, E/e prime will be measured and its change with baseline (before administration of the study drug) will be studied. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Comparison of change in e prime velocities between the groups 2) Comparison of change in E/A between the groups 3) Comparison of change in TRmax jet velocity between the groups 4) Comparison of change in LA volume indices be-tween the groups 5) Comparison of change in deceleration time between the groupsTimepoint: After the administration of the study drug, changes in the aforementioned parameters from the baseline will be studied | — |
Countries
India
Contacts
Public ContactSenthilnathan Muthapillai
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed