Health Condition 1: E273- Drug-induced adrenocortical insufficiency
Conditions
Interventions
None listed
Sponsors
Maulana Azad Medical College and associated Lok Nayak Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children and adolescents with steroid sensitive or steroid resistant nephrotic syndrome in the age group of 1-18 years, presently in remission (partial or complete) and 1. Who received daily prednisolone in any dosage for >= 2 weeks in the last 1 year and they are now off steroids or 2. Are presently receiving low dose alternate day prednisolone therapy (
Exclusion criteria
Exclusion criteria: 1. Children with nephrotic syndrome who received daily corticosteroid therapy in any dosages in the last 8 weeks. 2. Children with nephrotic syndrome having serious bacterial infections like pneumonia, cellulitis, sepsis, meningitis etc or are hospitalised for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients having adrenocortical insufficiency defined as serum cortisol 18 ug/dL by a low dose ACTH stimulation test. Timepoint: From OPD visit to individual patient samples will be analysed within five days. Thesis will be done in a year for the suggested sample size. | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease type, duration, cumulative steroid doses, correlation of steroid doses to baseline and stimulated serum cortisol values. Timepoint: From OPD visit to individual patient samples will be analysed within five days. Thesis will be done in a year for the suggested sample size. | — |
Countries
India
Contacts
Public ContactDrMukta Mantan
Maulana Azad Medical College and associated Lok Nayak Hospital
Outcome results
None listed