Health Condition 1: H160- Corneal ulcer Health Condition 2: H163- Interstitial and deep keratitis Health Condition 3: O- Medical and Surgical
Conditions
Interventions
Intervention1: Accelerated corneal collagen cross with standard anti fungal I.e, natamycin 5% eye drops: Surgical Technique: After topical anaesthesia with proparacaine hydrochloride 0.5% eye drops .
Sponsors
Dr Rajendra Prasad Institute for Ophthalmic Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1 Patients of smear positive fungal corneal ulcer and or demonstration of fungal hyphae in IVCM( In Vivo confocal microscopy ) 2 Size of ulcer more then 5 mm and stromal depth involvement more then 50 percent
Exclusion criteria
Exclusion criteria: 1 patients with corneal thickness less then 400 µm 2 Evidence of concomitant infection with herpes or bacterial 3 No perception of light in affected eye 4 Age less than 18 years or more than 70 years 5 Patients who were unable to complete follow up 6 Perforated corneal ulcer , corneal melting or perforation resulting to surgical intervention (therapeutic keratoplasty), endophthalmitis 7 Not willing to participate 8 Not able to come for follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage reduction in the infiltrate size after one and two weeks of the treatment in both armsTimepoint: 1 week ,2 week ,1 month ,3 month ,6 month | — |
Secondary
| Measure | Time frame |
|---|---|
| Time duration Taken took deduce the infiltrate size price 50% time taken for complete resolution of the ulcerTimepoint: 1 week ,2 week ,1 month ,3 month ,6 month | — |
Countries
India
Contacts
Public ContactDr Himanshu Khandelwal
Dr R P Centre of ophthalmology
Outcome results
None listed